Heather Chandler

Associate Professor

Contact Information

Postal address: 
338 W 10th Ave Room 562 Fry Hall Columbus, OH 43210

Biographical narrative

Dr. Heather Chandler received her PhD in veterinary biosciences from The Ohio State University evaluating epithelial-mesenchymal transition in the cornea and lens. She continued her training in the College of Veterinary Medicine as a post-doctoral researcher prior to co-managing core facilities in Veterinary Clinical Sciences. Dr. Chandler has been faculty in the College of Optometry since 2007.

While Dr. Chandler's primary research focus examines the mechanisms by which cataracts and secondary cataracts form, there are also several ongoing projects in the lab that pertain to protein regulation in the cornea. Current research includes reducing secondary cataract formation through either surgical or pharmacologic intervention and determining the effects of various ocular drugs on corneal would healing. The overall goal of her lab is to clinically apply bench-top research findings to the bedside.

Degrees

  • 2006, Ph.D., Ohio State University, The
  • 2001, B.S., University of Calgary

Journal articles

  • Chandler HL; Haeussler DJ; Gemensky-Metzler AJ; Wilkie DA; Lutz EA. "Induction of posterior capsule opacification by hyaluronic acid in an ex vivo model.." Investigative ophthalmology & visual science. Vol. 53, no. 4. (April 2012.): 1835-1845.
  • Chandler HL. "Ultraviolet absorption by contact lenses and the significance on the ocular anterior segment." Eye and Contact Lens. Vol. 37, (July 2011.): 259-66.
  • Powell DR, Thangavelu M, Chandler HL, Nichols KK, Nichols JJ. "Evaluation of extractants and precipitants in tear film proteomic analyses." Optometry and Vision Science. Vol. 87, no. 11. (November 2010.): 854-860.
  • Pannebaker C, Chandler HL, Nichols JJ. "Tear proteomics in keratoconus." Molecular Vision. Vol. 16, (October 2010.): 1949-1957.
  • Chandler HL, Webb TR, Barden CA, Thangavelu M, Kulp SK, Chen C-S, Colitz CMH. "The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model." Molecular Vision. Vol. 16, (October 2010.): 2202-14.
  • Chandler HL, Gemensky-Metzler AJ, Bras ID, Webb TE, Saville WJA, Colitz CMH. "In vivo effects of tetracycline on canine refractory ulcers." Journal of the American Veterinary Medical Association. Vol. 4, no. 237. (August 2010.): 378-386.
  • Long AC, Bomser JA, Grzybowski DM, Chandler HL. "All-trans retinoic acid regulates Cx43 expression, gap junction communication and differentiation in lens epithelial cells." Current Eye Research. Vol. 35, no. 8. (August 2010.): 670-679.
  • Newkirk KM, Haines DK, Calvarese ST, Esson DW, Chandler HL. "Distribution and amount of pigment within the ciliary body and iris or dogs with blue and brown irides." Veterinary Ophthalmology. Vol. 2, no. 13. (March 2010.): 76-80.
  • Chandler HL, Reuter KS, Sinnott LT, Nichols JJ. "Prevention of UV-induced damage to the anterior segment useing class I UV-absorbing hydrogel contact lenses." Investigative Ophthalmology and Visual Science. Vol. 51, no. 1. (January 2010.): 172-178.
  • Pot SA, Chandler HL, Colitz CHM, Bentley E, Dubielzig RR, Mosley TS, Reid TW, Murphy CJ. "Selenium functionalized intraocular lenses inhibit posterior capsule opacification in an ex vivo canine lens capsular bag assay.." Experimental Eye Research. Vol. 89, no. 5. (November 2009.): 728-734.
  • Colitz CMH, Sugimoto Y, Lu P, Barden CA, Thomas-Ahner J, Chandler HL. "ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells." Molecular Vision. Vol. 15, (November 2009.): 2259-2267.
  • Hudson LG, Newkirk KM, Chandler HL, Choi C, Fossey SL, Parent AE, Kusewitt DF. "Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)." Journal of Dermatological Science. Vol. 56, no. 1. (October 2009.): 19-26.
  • Chandler HL, Newkirk KM, Kusewitt DF, Dubielzig RR, Colitz CMH. "Immunohistochemical analysis of ocular hemangiomas and hemangiosarcomas in dogs." Veterinary Ophthalmology. Vol. 12, no. 2. (March 2009.): 83-90.
  • Chandler HL; Newkirk KM; Kusewitt DF; Dubielzig RR; Colitz CM. "Immunohistochemical analysis of ocular hemangiomas and hemangiosarcomas in dogs.." Veterinary Ophthalmology. Vol. 12, no. 2. (January 2009.): 83-90.
  • Gilger BC, Salmon JH, Yi NY, Barden CA, Chandler HL, Wendt JA, Colitz CMH. "Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States." American Journal of Veterinary Research. Vol. 69, no. 10. (October 2008.): 1329-1335.
  • Newkirk KM, Duncan FJ, Brannick EM, Chandler HL, Parent AE, Kusewitt DF. "The acute cutaneous inflammatory response is attenuated in Slug-knockout mice." Laboratory Investigation. Vol. 88, no. 8. (August 2008.): 831-841.
  • Chandler HL, Kusewitt DF, Colitz CMH. "Modulation of matrix metalloproteinases by ultraviolet radiation in the canine cornea." Veterinary Ophthalmology. Vol. 11, no. 3. (May 2008.): 135-144.
  • Newkirk KM; Duncan FJ; Brannick EM; Chandler HL; Parent AE; Kusewitt DF. "The acute cutaneous inflammatory response is attenuated in Slug-knockout mice.." Laboratory Investigation; A Journal of Technical Methods and Pathology. Vol. 88, no. 8. (January 2008.): 831-841.
  • Chandler HL; Kusewitt DF; Colitz CM. "Modulation of matrix metalloproteinases by ultraviolet radiation in the canine cornea.." Veterinary Ophthalmology. Vol. 11, no. 3. (January 2008.): 135-144.
  • Barden CA; Chandler HL; Lu P; Bomser JA; Colitz CM. "Effect of grape polyphenols on oxidative stress in canine lens epithelial cells.." American Journal Of Veterinary Research. Vol. 69, no. 1. (January 2008.): 94-100.
  • Gilger BC; Salmon JH; Yi NY; Barden CA; Chandler HL; Wendt JA; Colitz CM. "Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States.." American Journal Of Veterinary Research. Vol. 69, no. 10. (January 2008.): 1329-1335.
  • Newkirk KM, Parent AE, Fossey SL, Choi C, Chandler HL, Rajala-Schultz PJ, Kusewitt DF. "Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis." American Journal of Pathology. Vol. 171, no. 5. (November 2007.): 1629-1639.
  • Newkirk KM; Chandler HL; Parent AE; Young DC; Colitz CM; Wilkie DA; Kusewitt DF. "Ultraviolet radiation-induced corneal degeneration in 129 mice.." Toxicologic Pathology. Vol. 35, no. 6. (October 2007.): 819-826.
  • Newkirk KM, Chandler HL, Parent AE, Young DC, Wilkie DA, Kusewitt DF. "Ultraviolet radiation-induced corneal degeneration in 129 mice." Toxicologic Pathology. Vol. 35, no. 6. (October 2007.): 817-824.
  • Chandler HL, Barden CA, Lu P, Kusewitt DF, Colitz CMH. "Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition." Molecular Vision. Vol. 13, (April 2007.): 677-691.
  • Chandler HL, Colitz CMH, Lu P, Saville WJA, Kusewitt DF. "The role of the slug transcription factor in cell migration during corneal re-epithelialization in the dog." Experimental Eye Research. Vol. 84, no. 3. (March 2007.): 400-411.
  • Bras ID, Colitz CMH, Kusewitt DF, Chandler HL, Lu P, Gemensky-Metzler AJ, Wilkie DA. "Evaluation of advanced glycation end-products in diabetic and inherited canine cataracts." Graefe's Archive for Clinical and Experimental Ophthalmology. Vol. 245, no. 2. (February 2007.): 249-257.
  • Newkirk KM; Parent AE; Fossey SL; Choi C; Chandler HL; Rajala-Schultz PJ; Kusewitt DF. "Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis.." The American Journal Of Pathology. Vol. 171, no. 5. (January 2007.): 1629-1639.
  • Bras ID; Colitz CM; Kusewitt DF; Chandler HL; Lu P; Gemensky-Metzler AJ; Wilkie DA. "Evaluation of advanced glycation end-products in diabetic and inherited canine cataracts.." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Vol. 245, no. 2. (January 2007.): 249-257.
  • Chandler HL; Colitz CM; Lu P; Saville WJ; Kusewitt DF. "The role of the slug transcription factor in cell migration during corneal re-epithelialization in the dog.." Experimental Eye Research. Vol. 84, no. 3. (January 2007.): 400-411.
  • Chandler HL; Barden CA; Lu P; Kusewitt DF; Colitz CM. "Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition.." Molecular Vision. Vol. 13, (January 2007.): 677-691.
  • Klosterman E, Colitz CMH, Chandler HL, Kusewitt DF, Saville WJA, Dubielzig RR. "Immunohistochemical properties of ocular adenomas, adenocarcinomas and medulloepitheliomas." Veterinary Ophthalmology. Vol. 9, no. 6. (November 2006.): 387-394.
  • Klosterman E; Colitz CM; Chandler HL; Kusewitt DF; Saville WJ; Dubielzig RR. "Immunohistochemical properties of ocular adenomas, adenocarcinomas and medulloepitheliomas.." Veterinary Ophthalmology. Vol. 9, no. 6. (November 2006.): 387-394.
  • Colitz CM; Barden CA; Lu P; Chandler HL. "Ultraviolet irradiation up-regulates telomerase transcription and activity in lens epithelial cells.." Veterinary Ophthalmology. Vol. 9, no. 5. (September 2006.): 379-385.
  • Chandler HL, Colitz CMH. "Molecular biology for the clinician: Understanding current methods." Journal of the American Animal Hospital Association. Vol. 42, no. 5. (September 2006.): 326-335.
  • Colitz CMH, Barden CA, Lu P, Chandler HL. "Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells." Molecular Vision. Vol. 12, no. 119-21. (September 2006.): 1067-1076.
  • Colitz CM; Barden CA; Lu P; Chandler HL. "Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells.." Molecular Vision. Vol. 12, (September 2006.): 1067-1076.
  • Colitz CMH, Barden CA, Lu P, Chandler HL. "Ultraviolet irradiation up-regulates telomerase transcription and activity in lens epithelial cells." Veterinary Ophthalmology. Vol. 9, no. 5. (September 2006.): 379-385.
  • Chandler HL; Colitz CMH. "Molecular biology for the clinician: understanding current methods.." Journal of the American Animal Hospital Association. Vol. 42, no. 5. (January 2006.): 326-335.
  • Spatola RA; Thangavelu M; Upadhyayula V; Lee S; Phelps MA; Chandler HL. "Analysis of transport and cytotoxicity of topical nalbuphine solution in corneal cells." American Journal of Veterinary Research. -.

Honors

  • First Place, Research Day, 2006 - 2006
  • First Place, Distinguished Graduate Seminar Award, 2006 - 2006
  • First Place, Research Day, 2005 - 2005
  • Travel Award to the 32nd Annual American Society for Photobiology Meeting, 2004 - 2004
  • First Place, Distinguished Graduate Seminar Award, 2004 - 2004
  • First Place, Distinguished Graduate Seminar Award, 2003 - 2003

Books

  • Chandler HL. Epithelial-Mesenchymal Transition in the Anterior Segment of the Eye. Columbus, OH, US|USA: The Ohio State University, College of Veterinary Medicine, January 2006.