Nathan Doble

Associate Professor

Contact Information

Postal address: 
338 W 10th Ave Room 435A Columbus, OH 43210

Biographical narrative

Dr. Nathan Doble joined the College of Optometry in July 2013 as an Associate Professor. Dr. Doble’s research interest is the design, development and construction of high resolution optical imaging systems for in-vivo visualization of the human retina at the cellular level. Such systems promise better understanding, earlier diagnosis and improved treatment of a range of retinal pathologies.

Dr. Doble was previously a faculty member at the New England College of Optometry (NECO), Boston, MA from 2008-2013.

Prior to NECO, Dr. Doble was co-founder of Iris AO Inc, a Berkeley, CA based company specializing in the application of adaptive optics (AO) to biomedical imaging and the construction of deformable mirrors using micro-electromechanical systems (MEMS) technology.

Dr. Doble holds M.Sci, M.Sc. and Ph.D. degrees in the fields of laser physics and adaptive optics. From 2000 until 2003 he was a research associate at the Center for Visual Science at the University of Rochester, NY in the laboratory of Dr. David Williams.

Journal articles

  • Wells-Gray, E. M., Choi, S. S., Slabaugh, M. A., Weber, P., & Doble, N. P. (2018). Inner Nuclear Layer Changes in Primary Open Angle Glaucoma Revealed through Adaptive Optics Optical Coherence Tomography. Journal of Glaucoma, 27(11), 1025-1028.
  • Wells-Gray, E. M., Doble, N. P., Ohr, M. P., & Choi, S. S. (2018). Structural Integrity of Individual Cone Photoreceptors after Short-Wavelength Subthreshold Micropulse Laser Therapy for Diabetic Macular Edema. Ophthalmic Surgical Lasers and Imaging, 49(12), 946-954.
  • Wells-Gray, E. M., Choi, S. S., Zawadzki, R. J., Finn, S. C., Greiner, C., Werner, J. S., & Doble, N. (2018). Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope. JOURNAL OF BIOMEDICAL OPTICS, 23(3), 15 pages. doi:10.1117/1.JBO.23.3.036003
  • Marcos, S., Werner, J. S., Burns, S. A., Merigan, W. H., Artal, P., Atchison, D. A., . . . Sincich, L. C. (2017). Vision science and adaptive optics, the state of the field. VISION RESEARCH, 132, 3-33. doi:10.1016/j.visres.2017.01.006
  • Wells-Gray, E. M., Choi, S. S., Bries, A., & Doble, N. (2016). Variation in rod and cone density from the fovea to the mid-periphery in healthy human retinas using adaptive optics scanning laser ophthalmoscopy. EYE, 30(8), 1135-1143.
  • Morris, H. J., Blanco, L., Codona, J. L., Li, S. L., Choi, S. S., & Doble, N. (2015). Directionality of individual cone photoreceptors in the parafoveal region. VISION RESEARCH, 117, 67-80. doi:10.1016/j.visres.2015.10.008
  • Morris, H. J., Codona, J. L., Blanco, L., & Doble, N. (2015). Rapid measurement of individual cone photoreceptor pointing using focus diversity. OPTICS LETTERS, 40(17), 3982-3985. doi:10.1364/OL.40.003982
  • JWST Segment Phasing using Differential Optical Transfer Functions (2015). Journal of Astronomical Telescopes, Instruments, and Systems, 1(2).
  • Measurement of the photoreceptor pointing in the living chick eye (2015). VISION RESEARCH, 109. doi:10.1016/j.visres.2015.01.025
  • Single Cell Imaging of the Chick Retina with Adaptive Optics (2011). CURRENT EYE RESEARCH, 36(10). doi:10.3109/02713683.2011.587934
  • Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging (2011). BRITISH JOURNAL OF OPHTHALMOLOGY, 95(1). doi:10.1136/bjo.2010.183756
  • In vivo imaging of the human rod photoreceptor mosaic (2011). OPTICS LETTERS, 36(1).
  • Spherical aberration yielding optimum visual performance: Evaluation of intraocular lenses using adaptive optics simulation (2009). JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 35(7). doi:10.1016/j.jcrs.2009.02.033
  • Role of high-order aberrations in senescent changes in spatial vision (2009). JOURNAL OF VISION, 9(2). doi:10.1167/9.2.24
  • Doble, N., Miller, D. T., Yoon, G., & Williams, D. R. (2007). Requirements for discrete actuator and segmented wavefront correctors for aberration compensation in two large populations of human eyes. APPLIED OPTICS, 46(20), 4501-4514. doi:10.1364/AO.46.004501
  • Photoreceptor counting and montaging of en-face retinal images from an adaptive optics fundus camera (2007). JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 24(5).
  • In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function (2006). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 47(5). doi:10.1167/iovs.05.0997
  • Effect of wavelength on in vivo images of the human cone mosaic (2005). JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 22(12).
  • High-resolution, in vivo retinal imaging using adaptive optics and its future role in ophthalmology (2005). EXPERT REVIEW OF MEDICAL DEVICES, 2(2). doi:10.1586/17434440.2.2.205
  • Putnam, N. M., Hofer, H. J., Doble, N., Chen, L., Carroll, J., & Williams, D. R. (2005). The locus of fixation and the foveal cone mosaic. JOURNAL OF VISION, 5(7), 632-639. doi:10.1167/5.7.3
  • Doble, N., & Williams, D. R. (2004). The application of MEMS technology for adaptive optics in vision science. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 10(3), 629-635. doi:10.1109/JSTQE.2004.829202
  • Doble, N., Yoon, G., Chen, L., Bierden, P., Singer, B., Olivier, S., & Williams, D. R. (2002). Use of a microelectromechanical mirror for adaptive optics in the human eye. OPTICS LETTERS, 27(17), 1537-1539. doi:10.1364/OL.27.001537

Honors

  • 1st Place Purdue Life Sciences Business Plan Competition ($60,000), 20030401
  • 1st Place Fourth Annual UC Berkeley Business Plan Competition ($50,000), 20020401
  • 1st Place MBA Jungle Second Annual Business Plan Competition ($25,000), 20020401

Presentations

  • Doble, N. P. (n.d.). AO Retinal Imaging at OSU. In Center for Adaptive Optics (CfAO) Fall Retreat - Lake Arrowhead, CA.
  • Doble, N. P. (n.d.). Optical Coherence Tomography (OCT): How does it work? what can you see? what does the future hold?. In Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference, Lewis Center, OH.
  • Doble, N. P. (n.d.). Imaging the Invisible: Imaging Individual Retinal Ganglion Cells in the Living Human Eye. In Prevent Blindness Ohio: Aging Eye Summit.
  • Doble, N. P. (n.d.). Imaging Retinal Disease with Adaptive Optics Optical Coherence Tomography. In Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference.
  • Doble, N. P. (n.d.). Retinal Imaging Using Adaptive Optics. In OSU Department of Biomedical Engineering.
  • Doble, N. P. (n.d.). Integrity of Individual Cone Photoreceptors Over Drusen in Early Stage Dry AMD. In Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference.
  • High Resolution Retinal Imaging Using Adaptive Optics (n.d.). In OSU Department of Biomedical Engineering.
  • High Resolution Retinal Imaging Using Adaptive Optics (n.d.). In Oxyopia Research Lecture Series. Indiana University.
  • Doble, N. P. (n.d.). High Resolution Retinal Imaging. In Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference.
  • High Resolution Retinal Imaging (n.d.). In Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference.
  • Adaptive Optics Retinal Imaging (n.d.). In New England College of Optometry (NECO) Laboratory Survey Course. Boston.
  • Application of Adaptive Optics to Retinal Imaging and Vision Testing (n.d.). In Massachusetts Society of Optometrists (MSO). Southborough.
  • Adaptive Optics Retinal Imaging (n.d.). In New England College of Optometry (NECO) Laboratory Survey Course. Boston.
  • Adaptive Optics Retinal Imaging (n.d.). In New England College of Optometry (NECO) Summer Residency Conference. Boston.
  • The Application of Adaptive Optics to Vision Science (n.d.). In New England College of Optometry (NECO) Alumni Conference. Boston.
  • The Application of Adaptive Optics to Vision Science and Ophthalmology (n.d.). In U. Mass Medical Center – Worchester. Worchester.
  • The Application of Adaptive Optics to Vision Science (n.d.). In New England College of Optometry (NECO) Summer Residency Conference. Boston.
  • Application of Adaptive Optics in Vision Science (n.d.). In Schnurmacher Institute for Vision Research Colloquium, State University of New York Optometry School, (SUNY),. New York.
  • Adaptive Optics Retinal Imaging (n.d.). In New England College of Optometry (NECO) Laboratory Survey Course. Boston.
  • Adaptive Optics for Vision Science (n.d.). In New England College of Optometry (NECO) Research Seminar. Boston.
  • Current MEMS Status and Projects at Iris AO Inc (n.d.). In NSF Center for Adaptive Optics (CfAO) Fall Retreat. Yosemite.
  • Retinal Imaging with Adaptive Optics (n.d.). In Stanford University Photonics Research Center Symposium. Stanford.
  • High Stroke MEMS DM for Vision Science (n.d.). In National Eye Institute - BioEngineering Research Partnership Annual Meeting. University of California at Davis. Davis.
  • Vision Testing and High Resolution Retinal Imaging Using Adaptive Optics (n.d.). In Grand Rounds Presentation, California Pacific Medical Center. San Francisco.
  • MEMS Deformable Mirrors for Adaptive Optics (n.d.). In NSF Center for Adaptive Optics (CfAO) Thirty Meter Telescope MEMS DM Workshop. Santa Cruz.
  • High Performance MEMS Deformable Mirrors for Adaptive Optics (n.d.). In Applied Physics 483 Optics and Electronics Seminar, Stanford University. Stanford.
  • High Resolution Retinal Imaging Using Adaptive Optics (n.d.). In Dept. of Ophthalmology, Stanford University. Stanford.
  • High Resolution Imaging with a Microelectromechanical (MEMS) Mirror (n.d.). In NSF Center for Adaptive Optics (CfAO) Fall Retreat. Santa Cruz.
  • Measurement and Correction of the Aberrations of the Human Eye (n.d.). In NSF Center for Adaptive Optics (CfAO) Summer School. Santa Cruz.
  • High Resolution Retinal Imaging with a Microelectromechanical (MEMS) Mirror (n.d.). In University of Rochester, Center for Visual Science's 23rd Symposium “Engineering the Eyeâ€�. Rochester.
  • The Use of a MEMS Mirror for Adaptive Optics in the Human Eye (n.d.). In NSF Center for Adaptive Optics (CfAO) MEMS Workshop. Santa Cruz.
  • Design and performance of an adaptive optical system for the human eye (n.d.). In Integrating Research and A Conference for the Graduate Students and Postdoctoral Researchers of the NSF Center for Adaptive Optics (CfAO). Kona.
  • A MEMS Mirror for Adaptive Optics in the Human Eye (n.d.). In NSF Center for Adaptive Optics (CfAO) Fall Retreat. Monterey.
  • A MEMS Mirror for Adaptive Optics in the Human Eye (n.d.). In OSA Annual Meeting and Exhibit. Long Beach.
  • The Use of a MEMS Mirror for Adaptive Optics in the Human Eye (n.d.). In NSF Center for Adaptive Optics Summer School. Santa Cruz.
  • Adaptive optical system design and optimization for the human eye (n.d.). In SPIE Opto-North East and Imaging. Rochester.
  • High Resolution The Use of Microelectromechanical (MEMS) and Liquid Crystal Technology for Adaptive Optics in the Human Eye (n.d.). In Opto-North East and Imaging. Rochester.
  • Applications of Adaptive Optics to Vision Sciences (n.d.). In SPIE Opto-North East and Imaging. Rochester.
  • Design and performance of Rochester's 2nd generation adaptive optics system for the human eye (n.d.). In International Symposium: Adaptive Optics: From Telescopes to the Human Eye. Murcia.
  • Indirect Wavefront Sensing by Dithering (n.d.). In Wavefront Sensing and its Applications’, Institute of Physics. Canterbury.
  • Williams, D. R., & Liang, J. (1996). Adaptive optics for high resolution retinal imaging. Retrieved from http://gateway.webofknowledge.com/
  • Roorda, A., & Williams, D. R. (2000). Adaptive optics and retinal imaging. In Topical Meeting on Visual Science and its Applications. SANTA FE, NM. Retrieved from http://gateway.webofknowledge.com/

Chapters

  • Chapter Title: Adaptive Optics and OCTBook Title: Handbook of Visual OpticsRIV Chapter Authors: N DobleRIV Editors: P ArtalPublication Status: ForthcomingReviewed Item?: trueType of Review: Editor-ReviewPercent Authorship: 100
  • Chapter Title: The Human Eye and Adaptive OpticsBook Title: Topics in Adaptive OpticsRIV Chapter Authors: FA Vera-Diaz, N DobleRIV Editors: Robert TysonPublication Status: PublishedPublication date: June 2012Publisher: Intech Publishing, .Reviewed Item?: trueType of Review: Editor-ReviewPercent Authorship: 50
  • Chapter Title: MEMS Adaptive OpticsBook Title: Encylopedia of NanotechnologyRIV Chapter Authors: N DobleRIV Editors: B BhushanPublication Status: PublishedPublication date: June 2012Publisher: Springer Netherlands, .Reviewed Item?: trueType of Review: Editor-ReviewPercent Authorship: 100
  • Chapter Title: Wavefront Correctors for Vision ScienceBook Title: Adaptive optics for vision science: principles, practices, design, and applicationsRIV Chapter Authors: N Doble, DT MillerRIV Book Authors: Porter, JasonPublication Status: PublishedPublication date: January 2006Publisher: Wiley-Interscience, Hoboken, NJISBN-13: 9780471679417Reviewed Item?: trueType of Review: Editor-ReviewPercent Authorship: 70

Patents

  • RAPID MEASUREMENT OF INDIVIDUAL CONE PHOTORECEPTOR POINTING FOR EVALUATION OF EYE HEALTH USING FOCUS DIVERSITY (2016, April). 9999999.