Timothy Plageman

Associate Professor

Contact Information

Postal address: 
338 W 10th Ave Room 460 Columbus, OH 43210

Biographical narrative

Dr. Timothy Plageman received his PhD in Molecular and Developmental Biology at the University of Cincinnati.  He continued his training at Cincinnati Children’s Hospital Research Foundation as a post-doctoral researcher studying mechanisms of ocular development and joined the faculty in the College of Optometry at The Ohio State University in 2013.  A major goal of his research is to elucidate how embryonic eye tissues shape themselves during development at a cellular and molecular level and how disruptions in these mechanisms lead to ocular malformations or disease. To accomplish this goal, embryonic development of the eye is studied in both the mouse and chicken model systems and a variety of techniques are utilized that include static and live fluorescence microscopy, electron microscopy, histology, and molecular biology. 

Journal articles

  • Jessica, M., Muccioli, M., Herman, K., Finnell, R., & Plageman, T. (2019). Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism. Biology Open. doi:10.1242/bio.041160
  • Lopez-Escobar, B., Manuel Caro-Vega, J., Vijayraghavan, D. S., Plageman, T. F., Sanchez-Alcazar, J. A., Carlos Moreno, R., . . . Ybot-Gonzalez, P. (2018). The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. DEVELOPMENT, 145(9), 15 pages. doi:10.1242/dev.157487
  • Kaya, N., Alsagob, M., D'Adamo, M. C., Al-Bakheet, A., Hasan, S., Muccioli, M., . . . Al-Owain, M. (2016). KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataract and intellectual disability. JOURNAL OF MEDICAL GENETICS, 53(11), 786-792. doi:10.1136/jmedgenet-2015-103637
  • Muccioli, M., Qaisi, D., Herman, K., & Plageman, T. F. (2016). Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition. DEVELOPMENTAL BIOLOGY, 412(1), 32-43. doi:10.1016/j.ydbio.2016.02.016
  • Loebel, D. A. F., Plageman, T. F., Tang, T. L., Jones, V. J., Muccioli, M., & Tam, P. P. L. (2016). Thyroid bud morphogenesis requires CDC42-and SHROOM3-dependent apical constriction. BIOLOGY OPEN, 5(2), 130-139. doi:10.1242/bio.014415
  • Epithelial Morphogenesis: The Mouse Eye as a Model System (2015). NEURAL CREST AND PLACODES, 111. doi:10.1016/bs.ctdb.2014.11.011
  • Das, D., Zalewski, J. K., Mohan, S., Plageman, T. F., VanDemark, A. P., & Hildebrand, J. D. (2014). The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice. BIOLOGY OPEN, 3(9), 850-860. doi:10.1242/bio.20147450
  • Lang, R. A., Herman, K., Reynolds, A. B., Hildebrand, J. D., & Plageman, T. F. (2014). p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis. DEVELOPMENT, 141(16), 3177-3187. doi:10.1242/dev.107433
  • Plageman, T. F., & Lang, R. A. (2012). Generation of an Rx-tTA: TetOp-Cre Knock-In Mouse Line for Doxycycline Regulated Cre Activity in the Rx Expression Domain. PLOS ONE, 7(11), 6 pages. doi:10.1371/journal.pone.0050426
  • Plageman, T. F., Chauhan, B. K., Yang, C., Jaudon, F., Shang, X., Zheng, Y., . . . Lang, R. A. (2011). A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. DEVELOPMENT, 138(23), 5177-5188. doi:10.1242/dev.067868
  • Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis (2011). DEVELOPMENTAL BIOLOGY, 357(1). doi:10.1016/j.ydbio.2011.06.027
  • Plageman, T. F., Zacharias, A. L., Gage, P. J., & Lang, R. A. (2011). Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis. DEVELOPMENTAL BIOLOGY, 357(1), 227-234. doi:10.1016/j.ydbio.2011.06.027
  • Plageman, T. F., Chung, M. -I., Lou, M., Smith, A. N., Hildebrand, J. D., Wallingford, J. B., & Lang, R. A. (2010). Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination. DEVELOPMENT, 137(3), 405-415. doi:10.1242/dev.045369
  • Plageman, T. F., & Lang, R. A. (2009). Lens pit morphogenesis requires epithelial cell shape changes mediated by Shroom3. DEVELOPMENTAL BIOLOGY, 331(2), 447. doi:10.1016/j.ydbio.2009.05.225
  • Plageman, T. F., & Yutzey, K. E. (2006). Microarray analysis of Tbx5-induced genes expressed in the developing heart. DEVELOPMENTAL DYNAMICS, 235(10), 2868-2880. doi:10.1002/dvdy.20923
  • Plageman, T. F., & Yutzey, K. E. (2005). T-Box genes and heart development: Putting the "T" in HearT. DEVELOPMENTAL DYNAMICS, 232(1), 11-20. doi:10.1002/dvdy.20201
  • Plageman, T. F., & Yutzey, K. E. (2004). Differential expression and function of Tbx5 and Tbx20 in cardiac development. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(18), 19026-19034. doi:10.1074/jbc.M314041200


  • Basil O’Connor Starter Scholar Research Award, 20140201 - 20160201


  • Plageman, T. (n.d.). The epithelial cell behaviors that drive lens placode invagination. In ISER 2018.
  • Heimlich, D., Martin, J., & Plageman, T. (n.d.). Anisotropic lens fiber cell geometry is regulated by Shroom3 and Rho-kinase junctional contraction. In International Conference on the Lens.
  • Houssin, N., Herman, K., Yoon, S. O., & Plageman, T. (n.d.). Characterization of epithelial cell rearrangements during lens placode invagination. In International Conference on the Lens.
  • Lens placode cell anisotropic geometry is mediated by planar polarized inhibition of junctional contraction during invagination. (n.d.). In Visual System Development Gordon Research Conference.
  • Planar polarized cell behaviors as a force for lens placode invagination (n.d.). In International Conference on the Lens.
  • Plageman, T. F. (2016). Anisotropic geometry of lens placode cells is mediated by planar polarized inhibition of junctional contraction during invagination.. In Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO). Seattle, WA. Retrieved from http://gateway.webofknowledge.com/
  • Plageman, T. F., Reynolds, A., & Lang, R. A. (2014). Junctional p120-catenin Recruitment of Shroom3 Facilitates Apical Constriction During Lens Pit Morphogenesis. Retrieved from http://gateway.webofknowledge.com/


  • Chapter Title: Lens determination and inductionBook Title: Encyclopedia of the EyeRIV Chapter Authors: Plageman, TF Jr, Chauhan, BK, Lang, RARIV Editors: Dartt, DA, Beebe, DCPublication Status: PublishedPublication date: January 2010Publisher: Elsevier, Boston, United StatesEdition: 1stISBN-13: 9780123741981Reviewed Item?: trueType of Review: Editor-ReviewPercent Authorship: 100